A Guide to Taking Low Dose Naltrexone (LDN)

When to Take It

• Timing: Most providers recommend taking LDN in the evening or before bed. However, follow the schedule your provider has prescribed for you.
• Consistency: Take it at the same time each day to support stable blood levels and therapeutic benefits.

How to Take It

• Use Water Only: Take the capsule or tablet with a full glass of water.
• Do Not Alter the Tablet: Do not split, crush, or chew the medication.
• Wait to Eat or Drink: Follow your provider’s instructions regarding timing—most patients take it at night, but this may vary. You do not need to wait to eat or drink unless otherwise instructed.

What to Avoid

• Alcohol or Opioids: Do not use opioids or opioid-containing medications while taking LDN. It can block their effects and cause withdrawal.
• Dose Skipping: Do not double up if you miss a dose. Simply take your next scheduled dose.
• Sudden Changes: Avoid adjusting your dose without consulting your provider.

Storage Instructions

• Temperature: Store at room temperature, away from direct sunlight and moisture.
• Keep Secure: Ensure the medication is kept in a child-proof, clearly labeled container.
• Liquid Form: If using a compounded liquid version, refrigerate if instructed and shake well before each use

Additional Tips

• Sleep Changes: Some users report vivid dreams or disrupted sleep in the first few weeks. These often resolve over time.
• Track Your Response: Keep a journal to monitor symptoms, mood, and energy levels.
• Side Effects: May include sleep changes, mild headache, or digestive upset. These are typically temporary. Contact your provider if symptoms persist or worsen.