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How to Take Oral Semaglutide

A Guide to Taking Oral Semaglutide

This quick guide walks you through how to properly take oral semaglutide to ensure maximum effectiveness and safety. You’ll learn when and how to take your dose, what to avoid before and after, and how to build a consistent routine. Each step is designed to make the process simple, reliable, and effective—supporting your health goals with confidence.

When to Take It

  • Timing: Take your dose once daily in the morning, immediately after waking up.
  • Empty Stomach: Make sure your stomach is empty—do not eat, drink, or take any other medications before your dose.

How to Take It

  • Use Water Only: Swallow the tablet whole with no more than 4 ounces (about 120 mL) of plain water.
  • Do Not Alter the Tablet: Do not split, crush, or chew it.
  • Wait to Eat or Drink: After taking the tablet, wait at least 30 minutes before consuming anything else—including food, drinks, or other medications.

What to Avoid

  • Other Liquids: Do not take with anything other than plain water.
  • Food and Medications: Avoid all food, beverages, and oral medications for at least 30 minutes post-dose.
  • Tablet Alteration: Never crush, split, or chew the tablet.
  • Missed Dose: If you miss a dose, skip it and resume your schedule the next day. Do not double up.

Storage Instructions

  • Keep in Original Packaging: Store tablets in the original bottle with the cap tightly closed.
  • Temperature: Store at room temperature between 68°F and 77°F (20°C to 25°C).
  • Avoid Pill Organizers: Do not transfer tablets to alternate containers.

Additional Tips

  • Be Consistent: Take your tablet at the same time each day.
  • Track Your Progress: Monitor your weight and blood sugar levels regularly, or as directed.
  • Common Side Effects: May include nausea, diarrhea, decreased appetite, or constipation. Contact your provider if symptoms persist.
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Prescription products require an online evaluation by a licensed medical provider. Medications are prescribed by licensed clinicians as part of the YupMD program. Actual product packaging may vary. The FDA does not review compounded medications for safety or effectiveness. For prescription items, YupMD will arrange a consultation with a qualified healthcare provider. If approved, prescriptions will be filled by one of our partner pharmacies.

Note: These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease.

YupMD connects patients with independent licensed care providers who may prescribe compounded GLP-1 medications that have not been reviewed or approved by the FDA for safety or effectiveness. These medications may be dispensed by state-licensed 503A compounding pharmacies as part of personalized care. YupMD does not prescribe, manufacture, or distribute GLP-1 medications, and does not offer or distribute branded medications. We are not affiliated with or endorsed by any brand-name manufacturer. Prescription products require an online evaluation by a licensed medical provider, and actual product packaging may vary. Results vary. Restrictions apply. These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. See website for full details.